Localized Unresectable
Despite being a localized mass, the tumor may be unresectable because crucial blood vessel structures are involved or because the liver is impaired.

Standard Treatment  There is no standard therapy, so patients should be considered for clinical trials .

Two-Year Survival  Less than 5 percent 

Investigational 
• Cryosurgery holds some promise to allow the shrinkage of otherwise unresectable tumors, but the technique
  is done only by a few specialized physicians.

Advanced Disease 
The tumor involves all lobes of the liver and/or has spread to involve other organs such as the lungs, intra-abdominal lymph nodes or bone.